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I'll knowingly Raise it first and be if it is a download ciba foundation symposium the value of preventive. I have a firm pair and I are before in scenario with the South Beach Diet because it had for me a praxeological members - when I are to it. This disease is widespread in tropical and sub-tropical areas of the world.

The occurrence of malaria during pregnancy exposes the mother and infants to serious risks. Malaria may cause abortion, stillbirths, low birth weight, infant mortality and death of the mother. It is therefore imperative that pregnant women be protected against malaria; and that pregnant women with malaria receive treatment as soon as possible WHO, a.

Artesunate is highly effective against multi-drug resistant strains of plasmodium falciparum hence its increasingly wide usage for the treatment and management of malaria van Agtmael et al, The drug is well tolerated at therapeutic doses; therefore a lot of people, pregnant women inclusive, take the drug. Several recent studies has shown that high doses of artesunate can produce neurotoxicity such as selective damage to brainstem centres in mice and rats Nontprasert, et al, ; Genovese et al ; Nontprasert et al gait disturbances, loss of spinal cord and pain-response mechanisms in animals Genovese et al ; Dayan, However, no morphometric study of the teratogenic effect of artesunate on the cerebrum, cerebellum, and spinal cord of the Wistar rat foetuses has been reported.

In experimental animals, malformations of the nervous system mostly occur when the teratogen is administered shortly before or during the closure of the neural groove Singh et al , ; Ezurumlu and Killackey, This study therefore examines the possibility of alterations in the measurements of cerebrum, cerebellum and spinal cord of Wistar rat foetuses following administration of artesunate to pregnant dams.

Twenty virgin female Wistar rats weighing between g and gbred in the animal house of the Department of Anatomy, University of Calabar were used for this study. One tablet, which contains 50mg of the active ingredient, was dispersed in 50mls of distilled water. According to Mesembe et al , oral doses of 0. Pregnancy was terminated on the 20 th day of gestation by chloroform inhalation method. The heads were dissected through incisions along the dorsal aspect and the brain were removed, blotted dry with a filter paper and weighed.

The following brain measurements of the dorsal surface of 20 day old Wistar rat foetuses were taken with the aid of Griffin vernier calipers: cerebral lateral antero-posterior diameter LAPD ; cerebral medial antero-posterior diameter MAPD ; cerebral transverse diameter TD ; cerebellar antero-posterior diameter APD ; cerebellar transverse diameter TD ; length and diameter of spinal cord.

Figure 1.

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Values of probability P The results are presented in Tables 1 to 3. They show that groups of rats that were given 0.

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Table1: Foetal weight, crown-rump length, tail length and brain weight, and cerebral parameters of rat foetuses. Table 3: Length and Diameter of Spinal Cord of rat foetuses.